Cothera VPULSE Cold-Compression Therapy system is designed to fill the need for a preventative measure for DVT and PE, which are collectively known as venous thrombosis. DVT is the formation of a blood clot in a deep vein, and which most commonly occurs in the legs, while PE is the embolism of a pulmonary artery. Intermittent cryo-compression therapy is used to reduce swelling at the treatment site, while controlled cold therapy reduces both pain and swelling.